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GH-regulated STAT 5 has also been implicated in regulation of other physiologically important genes, including those encoding components of the IGF-I axis and insulin. Together, these studies provide insight into GH signaling mechanisms and diverse physiological roles of GH. Ghrelin is a new endogenous peptide, discovered in 1999 by Kojima et al., as the result of a search for an endogenous ligand for an orphan receptor of known structure and function. Ghrelin is composed of 28 amino acids and is produced mostly by cells of the stomach, hypothalamus, and hypophysis, but it has also been detected in other tissues. If you have already had chemotherapy, then you should check a semen analysis starting about one year after completion of the chemotherapy to see if sperm function is returning. The good news is that with modern technology you can father a child with a single motile sperm. As far as waiting, this depends on the particular chemotherapy agents and the regimen used. In general, we ask that men avoid conception for one to two years after chemotherapy has been completed.
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